Swimming Against the Current: Challenges on the Way to Scientific Discovery

Swimming Against the Current: Challenges on the Way to Scientific Discovery

Dr Donald G. Stein

10 July 2008

12.00pm - 2.30pm

SMU Admin Building

Singapore

Basic research is rarely a straight path to discovery. It usually takes many twists and turns over the course of a career. In the case of Dr Donald G. Stein, it took almost three decades to bring a simple, safe and effective treatment for traumatic brain injury and possibly other Central Nervous System disorders from the laboratory bench to the patient's bed.

In this lecture, Dr Stein, a Professor in Emergency Medicine and Neurology at Emory University's School of Medicine, discussed the ups and downs, and ins and outs of the investigative process, including the social, political, economic and scientific issues that present themselves along the way. He explained how these challenges provide focus, direction and a sense of purpose, even when the trajectory is frustrating, what is gratifying in a long a career in research and teaching.

  • Dr Stein's research challenges earlier scientific beliefs, showing that recovery of brain function and plasticity is possible despite injury.
  • The use of progesterone to treat traumatic brain injury is a breakthrough discovery that could lead the way for other medical treatments.
  • The trend of pharmaceutical companies buying smaller biotechnology companies instead of investing in R&D could impede drug discovery.

Speaker

Speaker
Dr Donald G. Stein

Asa G. Candler Professor in Emergency Medicine and Neurology
Emory University

  • On challenging long-standing scientific notions

    This was the dogma and wisdom of the day and it continued right up to the time I was a graduate student. If you take this as absolute faith, how could you possibly be looking at recovery of function and plasticity in the brain against this kind of concept? So this is what I was up against.

    This was the dogma and wisdom of the day and it continued right up to the time I was a graduate student. If you take this as absolute faith, how could you possibly be looking at recovery of function and plasticity in the brain against this kind of concept? So this is what I was up against.

    Dr Donald G. Stein
    Asa G. Candler Professor in Emergency Medicine and Neurology
    Emory University

Dr Donald G. Stein during his speech at Singapore Management University

Photo Gallery

Photo Gallery